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Leah VARDY
Understanding the drivers of epidermal pigmentation |
Abstract
In the human epidermis, pigmentation is a finely controlled process involving multiple cell types. Pigmentary disorders can arise when this control is disrupted. This talk will cover an overview of the process of melanogenesis and pigment production in the skin and highlight pathways that are involved in driving aberrant pigmentation. Epidermal pigmentation can be studied using a variety of cell models and these will be discussed. The role of the polyamines - a new driver of epidermal pigmentation will be presented along with potential clinical applications.
In the human epidermis, pigmentation is a finely controlled process involving multiple cell types. Pigmentary disorders can arise when this control is disrupted. This talk will cover an overview of the process of melanogenesis and pigment production in the skin and highlight pathways that are involved in driving aberrant pigmentation. Epidermal pigmentation can be studied using a variety of cell models and these will be discussed. The role of the polyamines - a new driver of epidermal pigmentation will be presented along with potential clinical applications.
Bio
Leah Vardy is a Senior Investigator at A*STARs Skin Research Laboratory and the Skin Research Institute of Singapore. Leah received her Ph.D at the Imperial Cancer Research Fund in London and did post-doctoral work at the Whitehead Institute in Cambridge at the MIT in the US. In 2007, she was appointed to A*STAR’s Institute of Medical Biology before joining SRIS in 2018. Leah has worked in a diverse array of systems including yeast, fruit flies, embryonic stem cells and epidermal cells. Her current research focuses on understanding how cellular behavior within the epidermis is controlled. Projects in the lab address this in the context of pigmentation, tissue repair and skin aging
Leah Vardy is a Senior Investigator at A*STARs Skin Research Laboratory and the Skin Research Institute of Singapore. Leah received her Ph.D at the Imperial Cancer Research Fund in London and did post-doctoral work at the Whitehead Institute in Cambridge at the MIT in the US. In 2007, she was appointed to A*STAR’s Institute of Medical Biology before joining SRIS in 2018. Leah has worked in a diverse array of systems including yeast, fruit flies, embryonic stem cells and epidermal cells. Her current research focuses on understanding how cellular behavior within the epidermis is controlled. Projects in the lab address this in the context of pigmentation, tissue repair and skin aging
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Steven THNG
What's new in pathogenesis of Melasma |
Abstract
Melasma is common in Asian population and can be one of the most difficult clinical condition to manage. To date, there is no universally effective way to eradicate melasma. Much research had gone into the science of pigmentary disorders and many new exciting knowledge had emerged from these research in recent years, promising new, novel and more effective treatment options for patients. This talk will provide new insights into the latest basic science data on melasma pathogenesis, concentrating on novel pathways that contribute the to pathogenesis of melasma. Understanding novel pathways will allow us to open up new therapeutic avenues for the treatment of melasma.
Melasma is common in Asian population and can be one of the most difficult clinical condition to manage. To date, there is no universally effective way to eradicate melasma. Much research had gone into the science of pigmentary disorders and many new exciting knowledge had emerged from these research in recent years, promising new, novel and more effective treatment options for patients. This talk will provide new insights into the latest basic science data on melasma pathogenesis, concentrating on novel pathways that contribute the to pathogenesis of melasma. Understanding novel pathways will allow us to open up new therapeutic avenues for the treatment of melasma.
Bio
Steven graduated from National University of Singapore in 1992 and went on to pursue his interest in Humanitarian and Disaster medicine with the Singapore Armed Forces from 1992 to 2002. After completing his dermatology training in Singapore, Steven went on to Amsterdam Medical Centre, Netherlands, to continue his training in pigmentary disorder, under Professor Westerhof. Upon returning from his training, Dr Steven Thng started the pigment clinic in National Skin Centre as well as set up the melanocyte culture lab to start his work on cultured melanocytes grafting for vitiligo patients. Currently, Dr Thng is the head of the pigment clinic, in charge of managing all complex pigmentary disorders in National Skin Centre, and he is also the principal surgeon for tissue grafting for vitiligo. Steven took over as executive director of Skin Research Institute of Singapore in Jan 2017, and is responsible for the transformation of SRIS from a virtual institute to a dynamic institute, working on 4 main multi-institutional, interdisciplinary research programs of chronic wound, acne, skin microbiome and atopic dermatitis. His current research interest is on skin pigmentary disorder, atopic dermatitis, novel drug delivery systems, as well as advanced imaging for skin cancer and skin diseases. He has translated much of his research to improve patient care in dermatology. For his dedication in research and patient care, he was awarded Excellence in Public Service Award in 2013, Healthcare Humanity Award in 2014, Singapore Clinician Investigator Award in 2015 and 2016.
Steven graduated from National University of Singapore in 1992 and went on to pursue his interest in Humanitarian and Disaster medicine with the Singapore Armed Forces from 1992 to 2002. After completing his dermatology training in Singapore, Steven went on to Amsterdam Medical Centre, Netherlands, to continue his training in pigmentary disorder, under Professor Westerhof. Upon returning from his training, Dr Steven Thng started the pigment clinic in National Skin Centre as well as set up the melanocyte culture lab to start his work on cultured melanocytes grafting for vitiligo patients. Currently, Dr Thng is the head of the pigment clinic, in charge of managing all complex pigmentary disorders in National Skin Centre, and he is also the principal surgeon for tissue grafting for vitiligo. Steven took over as executive director of Skin Research Institute of Singapore in Jan 2017, and is responsible for the transformation of SRIS from a virtual institute to a dynamic institute, working on 4 main multi-institutional, interdisciplinary research programs of chronic wound, acne, skin microbiome and atopic dermatitis. His current research interest is on skin pigmentary disorder, atopic dermatitis, novel drug delivery systems, as well as advanced imaging for skin cancer and skin diseases. He has translated much of his research to improve patient care in dermatology. For his dedication in research and patient care, he was awarded Excellence in Public Service Award in 2013, Healthcare Humanity Award in 2014, Singapore Clinician Investigator Award in 2015 and 2016.
Chairs
Aishwarya Sridharan, SRIS
Etienne Wang, NSC
Aishwarya Sridharan, SRIS
Etienne Wang, NSC