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WEDNESDAY 10th APRIL - DAY 1
08:00 – 16:00
REGISTRATION
09:00
CONFERENCE OPENING AND WELCOME
Oliver DREESEN
Skin Research Institute of Singapore, A*STAR, Singapore
Daisuke NANBA
Tokyo Medical and Dental University, Japan
09:15 – 10:35
SESSION 1: SKIN AGING AND HOMEOSTASIS
Chairs: David LANE and Daisuke NANBA
09:15 – 09:40
Emi NISHIMURA, Tokyo Medical and Dental University, Japan
Stem cell competition underlies skin homeostasis and aging
09:40 – 09:55
Pritinder KAUR, Curtin University, Australia
Decreased tissue regenerative potential of aging human skin can be attributed partly to changes in the dermal microenvironment
09:55 – 10:20
Oliver DREESEN, Skin Research Institute of Singapore, Singapore
The role of heterochromatin in the accelerated aging syndrome Hutchinson-Gilford Progeria (HGPS)
10:20 – 10:35
Kentaro KAJIYA, Shiseido Global Innovation Center, Japan
3-dimensional visualization of vasculature in skin and its relevance in skin aging
10:35 – 11:05
Morning tea break
11:05 – 12:40
SESSION 2: STEM CELLS AND REGENERATION I
Chairs: Nick BARKER and Aiko SADA
11:05 – 11:30
Sophie BELLANGER, Skin Research Institute of Singapore, Singapore
Nicotinamide metabolism modulates the proliferation-differentiation-senescence balance in human primary keratinocytes
11:30 – 11:45
Hirotaka TAKEUCHI, POLA Chemical Industries Inc, Japan
Mechanism of skin aging (wrinkle and sagging) – Focusing on dermis and hypodermis
11:45 – 12:00
Ken NATSUGA, Hokkaido University, Japan
Epidermal responses to physical stimuli
12:00 – 12:15
Toru HIRATSUKA, King's College London, UK
Pulse kinetics of ERK MAPK controls epidermal stem cell states
12:15 – 12:40
Toshio SUDA, National University of Singapore, Singapore
Quiescence and cell metabolism in stem cells
12:40 – 14:15
Lunch break
14:15 – 16:00
SESSION 3: STEM CELLS AND REGENERATION II
Chairs: Yann BARRANDON and Ken NATSUGA
14:15 – 14:40
Nick BARKER, Institute of Medical Biology, Singapore
LGR5+ stem cells in epithelial maintenance, repair and cancer of the stomach
14:40 – 14:55
Ryuichiro KURATA, Osaka University, Japan
Sweat gland stem cells in human sweat glands
14:55 – 15:20
Daisuke NANBA, Tokyo Medical and Dental University, Japan
Tracing stem cell motion in human keratinocyte colonies using deep learning-based object tracking
15:20 – 15:35
Jun-ichi SAKABE, Institute of Medical Biology, Singapore
Breaking boundaries: The tale of thymus and epidermis
15:35 – 16:00
Aiko SADA, University of Tsukuba, Japan
Maintenance of heterogeneous epidermal stem cell populations by the distinct niche
16:00 – 18:00
Poster Session
Wine and cheese
End of Day 1
THURSDAY 11th APRIL - DAY 2
08:30
REGISTRATION
09:00 – 10:35
Session 4: SKIN CANCER
Chairs: Oliver DREESEN and Pritinder KAUR
09:00 – 09:25
David LANE, A*STAR, Singapore
Regulation of expression of wild type and mutant p53 proteins in normal skin and in skin cancer
09:25 – 09:40
Audrey Wang, Skin Research Institute of Singapore, Singapore
A diagnostic toolkit to detect and quantify senescent cells in age-related skin pathologies
09:40 – 10:05
Kiarash KHOSROTEHRANI, The University of Queensland, Australia
Molecular determinants of endothelial cell hierarchy and plasticity: Functional consequences in skin and skin cancer
10:05 – 10:20
Daisuke UTSUMI, University of the Ryukyus, Japan
Identifying the origin of metastatic skin carcinoma of unknown primary site using machine learning approach based on transcriptome data
10:20 – 10:35
Karen CRASTA, Nanyang Technological University, Singapore
Cell non-autonomous effects of chemotherapy-induced delayed wound healing
10:35 – 11:05
Morning tea break
11:05 – 13:00
Session 5: SKIN DISEASES
Chairs: Riichiro ABE and Hideyuki UJIIE
11:05 – 11:30
Birgitte LANE, Skin Research Institute of Singapore, Singapore
What keratins do in skin
11:30 – 11:45
Osamu ANSAI, Niigata University, Japan
Aberrant keratin assembly causes impaired mitochondrial movement and function: Implications for epidermolysis bullosa simplex pathogenesis
11:45 – 12:10
Hideyuki UJIIE, Hokkaido University, Japan
Mechanism of autoantibody production in bullous pemphigoid
12:10 – 12:35
Riichiro ABE, Niigata University, Japan
Necroptosis in Stevens-Johnson syndrome/toxic epidermal necrolysis
12:35 – 13:00
Maurice VAN STEENSEL, Skin Research Institute Singapore, Singapore
Zebrafish in dermatology: Cans and cannots
13:00 – 14:30
Lunch break
14:30 – 16:05
Session 6: SKIN IMMUNOLOGY I
Chairs: Baptiste JANELA and Mariko MORIYAMA
14:30 – 14:55
Masayuki AMAGAI, Keio University, Japan
Stratum corneum as niche to control skin microbiota
14:55 – 15:10
Satoshi Nakamizo, Skin Research Institute Singapore & Singapore Immunology Network, Singapore
Neutrophilc folliculitis is facilitated by a Western diet via induction of follicular hyperkeratosis and activation of sebaceous cells
15:10 – 15:25
Sayuri YAMAZAKI, Nagoya City University, Japan
Skin dendritic cells expressing a unique set of genes associated with immunological tolerance are specialized to expand thymus-derived Foxp3+ regulatory T cells upon ultraviolet B exposure
15:25 – 15:40
Chisa NAKASHIMA, Kyoto University, Japan
Both basophils and peripheral nerves are involved in the development of Staphylococcus aureus-induced skin inflammation
15:40 – 16:05
Niranjan NAGARAJAN, Genome Institute of Singapore, Singapore
Skin microbiome dermotypes in atopic dermatitis are linked to host immunity and microbial virulence
16:05 – 16:35
Afternoon tea break
16:35 – 17:45
WOMEN IN SCIENCE KEYNOTE LECTURE
David LANE – Introduction
Yoshiko TAKAHASHI, Kyoto University, Japan
To live with neural crest cells, without which no one is happy
End of Day 2
FRIDAY 12th APRIL - DAY 3
08:30
REGISTRATION
09:00 – 10:20
SESSION 7: SKIN IMMUNOLOGY II
Chairs: Satoshi NAKAMIZO and Takehiko YOKOMIZO
09:00 – 09:25
Kenji KABASHIMA, Kyoto University, Japan
Cutaneous immune responses to external stimuli
09:25 – 09:40
James WELLS, The University of Queensland, Australia
Peripheral CD4+CD8+ T cells are a stable population that emerge from CD4+ T cells to mediate CD8+ T cell regulation in the skin
09:40 – 09:55
Mika TAKAICHI, Osaka City University, Japan
The effect of CRH on connective tissue- and mucosal-type mast cells degranulation and proliferation in situ ~CRH is a stimulator for mast cells~
09:55 – 10:20
Baptiste Janela, Skin Research Institute Singapore & Singapore Immunology Network, Singapore
Skin dendritic cells: The sentinel paradox
10:20 – 10:50
Morning tea break
10:50 – 12:35
SESSION 8: TECHNOLOGIES TO STUDY SKIN HEALTH
Chairs: Sierin LIM and James WELLS
10:50 – 11:15
Takehiko YOKOMIZO, Juntendo University, Japan
Roles of 12-HHT/BLT2 axis in skin
11:15 – 11:30
Daniel LIO, Nanyang Technological University, Singapore
Temporal pressure enhanced transdermal delivery through micropore formation
11:30– 11:55
Sierin LIM, Nanyang Technological University, Singapore
Protein cages for consumer care formulation
11:55 – 12:10
Yingrou TAN, Singapore Immunology Network & National Skin Center, Singapore
Three-dimensional optical clearing and imaging of pruritic atopic dermatitis and psoriasis skin reveals downregulation of epidermal innervation
12:10– 12:35
Markus WENK, National University of Singapore, Singapore
Translation of lipidomic technologies towards quantification of blood lipids.
12:35 – 14:05
Lunch break
14:05 – 15:30
SESSION 9: HAIR BIOLOGY AND SKIN BARRIER
Chairs: Carlos CLAVEL and Mayumi ITO
14:05 – 14:30
Colin JAHODA, Durham University, UK
The multifaceted roles of hair follicle mesenchymal cells and their epigenetic status in vivo and in vitro
14:30 – 14:45
Chin Yan LIM, Skin Research Institute of Singapore, Singapore
Dynamic changes in chromatin mediate epidermal development and keratinocyte function
14:45 – 15:00
Mikiro TAKAISHI, Kochi University, Japan
Ahed, an uncharacterized nuclear protein, is required for epidermal cell growth and differentiation
15:00 – 15:15
Nikolaos PANTELIREIS, Imperial College London, UK
Modelling epigenetic changes regulating hair follicle induction
15:15 – 15:30
Joy NG, Skin Research Institute of Singapore, Singapore
Sox2 in the dermal papilla regulates hair follicle pigmentation
15:30 – 16:00
Afternoon tea break
16:00 – 17:40
SESSION 10: HAIR BIOLOGY
Chairs: Colin JAHODA and Emi NISHIMURA
16:00 – 16:25
Mayumi ITO, New York University, USA
SHH signal in hair follicle neogenesis
16:25 – 16:40
Etienne Wang, National Skin Centre, Singapore
Oncostatin M from a distinct subset of TREM2+ macrophages inhibits hair follicle stem cells proliferation during telogen
16:40 – 16:55
Kenneth LAY, Institute of Medical Biology, Singapore
Hair follicle stem cells repurpose proliferation and recruit immune cells to contain a breach in their niche barrier
16:55 – 17:20
Hironobu FUJIWARA, RIKEN Center for Biosystems Dynamics Research, Japan
Developmental origin and induction processes of hair follicle stem cells
17:20 – 17:40
PRIZE CEREMONY AND CONFERENCE CLOSING
Thomas DAWSON, President, Skin Research Society Singapore
End of conference
CONFERENCE DINNER @ Privé, Asian Civilisations Museum
08:00 – 16:00
REGISTRATION
09:00
CONFERENCE OPENING AND WELCOME
Oliver DREESEN
Skin Research Institute of Singapore, A*STAR, Singapore
Daisuke NANBA
Tokyo Medical and Dental University, Japan
09:15 – 10:35
SESSION 1: SKIN AGING AND HOMEOSTASIS
Chairs: David LANE and Daisuke NANBA
09:15 – 09:40
Emi NISHIMURA, Tokyo Medical and Dental University, Japan
Stem cell competition underlies skin homeostasis and aging
09:40 – 09:55
Pritinder KAUR, Curtin University, Australia
Decreased tissue regenerative potential of aging human skin can be attributed partly to changes in the dermal microenvironment
09:55 – 10:20
Oliver DREESEN, Skin Research Institute of Singapore, Singapore
The role of heterochromatin in the accelerated aging syndrome Hutchinson-Gilford Progeria (HGPS)
10:20 – 10:35
Kentaro KAJIYA, Shiseido Global Innovation Center, Japan
3-dimensional visualization of vasculature in skin and its relevance in skin aging
10:35 – 11:05
Morning tea break
11:05 – 12:40
SESSION 2: STEM CELLS AND REGENERATION I
Chairs: Nick BARKER and Aiko SADA
11:05 – 11:30
Sophie BELLANGER, Skin Research Institute of Singapore, Singapore
Nicotinamide metabolism modulates the proliferation-differentiation-senescence balance in human primary keratinocytes
11:30 – 11:45
Hirotaka TAKEUCHI, POLA Chemical Industries Inc, Japan
Mechanism of skin aging (wrinkle and sagging) – Focusing on dermis and hypodermis
11:45 – 12:00
Ken NATSUGA, Hokkaido University, Japan
Epidermal responses to physical stimuli
12:00 – 12:15
Toru HIRATSUKA, King's College London, UK
Pulse kinetics of ERK MAPK controls epidermal stem cell states
12:15 – 12:40
Toshio SUDA, National University of Singapore, Singapore
Quiescence and cell metabolism in stem cells
12:40 – 14:15
Lunch break
14:15 – 16:00
SESSION 3: STEM CELLS AND REGENERATION II
Chairs: Yann BARRANDON and Ken NATSUGA
14:15 – 14:40
Nick BARKER, Institute of Medical Biology, Singapore
LGR5+ stem cells in epithelial maintenance, repair and cancer of the stomach
14:40 – 14:55
Ryuichiro KURATA, Osaka University, Japan
Sweat gland stem cells in human sweat glands
14:55 – 15:20
Daisuke NANBA, Tokyo Medical and Dental University, Japan
Tracing stem cell motion in human keratinocyte colonies using deep learning-based object tracking
15:20 – 15:35
Jun-ichi SAKABE, Institute of Medical Biology, Singapore
Breaking boundaries: The tale of thymus and epidermis
15:35 – 16:00
Aiko SADA, University of Tsukuba, Japan
Maintenance of heterogeneous epidermal stem cell populations by the distinct niche
16:00 – 18:00
Poster Session
Wine and cheese
End of Day 1
THURSDAY 11th APRIL - DAY 2
08:30
REGISTRATION
09:00 – 10:35
Session 4: SKIN CANCER
Chairs: Oliver DREESEN and Pritinder KAUR
09:00 – 09:25
David LANE, A*STAR, Singapore
Regulation of expression of wild type and mutant p53 proteins in normal skin and in skin cancer
09:25 – 09:40
Audrey Wang, Skin Research Institute of Singapore, Singapore
A diagnostic toolkit to detect and quantify senescent cells in age-related skin pathologies
09:40 – 10:05
Kiarash KHOSROTEHRANI, The University of Queensland, Australia
Molecular determinants of endothelial cell hierarchy and plasticity: Functional consequences in skin and skin cancer
10:05 – 10:20
Daisuke UTSUMI, University of the Ryukyus, Japan
Identifying the origin of metastatic skin carcinoma of unknown primary site using machine learning approach based on transcriptome data
10:20 – 10:35
Karen CRASTA, Nanyang Technological University, Singapore
Cell non-autonomous effects of chemotherapy-induced delayed wound healing
10:35 – 11:05
Morning tea break
11:05 – 13:00
Session 5: SKIN DISEASES
Chairs: Riichiro ABE and Hideyuki UJIIE
11:05 – 11:30
Birgitte LANE, Skin Research Institute of Singapore, Singapore
What keratins do in skin
11:30 – 11:45
Osamu ANSAI, Niigata University, Japan
Aberrant keratin assembly causes impaired mitochondrial movement and function: Implications for epidermolysis bullosa simplex pathogenesis
11:45 – 12:10
Hideyuki UJIIE, Hokkaido University, Japan
Mechanism of autoantibody production in bullous pemphigoid
12:10 – 12:35
Riichiro ABE, Niigata University, Japan
Necroptosis in Stevens-Johnson syndrome/toxic epidermal necrolysis
12:35 – 13:00
Maurice VAN STEENSEL, Skin Research Institute Singapore, Singapore
Zebrafish in dermatology: Cans and cannots
13:00 – 14:30
Lunch break
14:30 – 16:05
Session 6: SKIN IMMUNOLOGY I
Chairs: Baptiste JANELA and Mariko MORIYAMA
14:30 – 14:55
Masayuki AMAGAI, Keio University, Japan
Stratum corneum as niche to control skin microbiota
14:55 – 15:10
Satoshi Nakamizo, Skin Research Institute Singapore & Singapore Immunology Network, Singapore
Neutrophilc folliculitis is facilitated by a Western diet via induction of follicular hyperkeratosis and activation of sebaceous cells
15:10 – 15:25
Sayuri YAMAZAKI, Nagoya City University, Japan
Skin dendritic cells expressing a unique set of genes associated with immunological tolerance are specialized to expand thymus-derived Foxp3+ regulatory T cells upon ultraviolet B exposure
15:25 – 15:40
Chisa NAKASHIMA, Kyoto University, Japan
Both basophils and peripheral nerves are involved in the development of Staphylococcus aureus-induced skin inflammation
15:40 – 16:05
Niranjan NAGARAJAN, Genome Institute of Singapore, Singapore
Skin microbiome dermotypes in atopic dermatitis are linked to host immunity and microbial virulence
16:05 – 16:35
Afternoon tea break
16:35 – 17:45
WOMEN IN SCIENCE KEYNOTE LECTURE
David LANE – Introduction
Yoshiko TAKAHASHI, Kyoto University, Japan
To live with neural crest cells, without which no one is happy
End of Day 2
FRIDAY 12th APRIL - DAY 3
08:30
REGISTRATION
09:00 – 10:20
SESSION 7: SKIN IMMUNOLOGY II
Chairs: Satoshi NAKAMIZO and Takehiko YOKOMIZO
09:00 – 09:25
Kenji KABASHIMA, Kyoto University, Japan
Cutaneous immune responses to external stimuli
09:25 – 09:40
James WELLS, The University of Queensland, Australia
Peripheral CD4+CD8+ T cells are a stable population that emerge from CD4+ T cells to mediate CD8+ T cell regulation in the skin
09:40 – 09:55
Mika TAKAICHI, Osaka City University, Japan
The effect of CRH on connective tissue- and mucosal-type mast cells degranulation and proliferation in situ ~CRH is a stimulator for mast cells~
09:55 – 10:20
Baptiste Janela, Skin Research Institute Singapore & Singapore Immunology Network, Singapore
Skin dendritic cells: The sentinel paradox
10:20 – 10:50
Morning tea break
10:50 – 12:35
SESSION 8: TECHNOLOGIES TO STUDY SKIN HEALTH
Chairs: Sierin LIM and James WELLS
10:50 – 11:15
Takehiko YOKOMIZO, Juntendo University, Japan
Roles of 12-HHT/BLT2 axis in skin
11:15 – 11:30
Daniel LIO, Nanyang Technological University, Singapore
Temporal pressure enhanced transdermal delivery through micropore formation
11:30– 11:55
Sierin LIM, Nanyang Technological University, Singapore
Protein cages for consumer care formulation
11:55 – 12:10
Yingrou TAN, Singapore Immunology Network & National Skin Center, Singapore
Three-dimensional optical clearing and imaging of pruritic atopic dermatitis and psoriasis skin reveals downregulation of epidermal innervation
12:10– 12:35
Markus WENK, National University of Singapore, Singapore
Translation of lipidomic technologies towards quantification of blood lipids.
12:35 – 14:05
Lunch break
14:05 – 15:30
SESSION 9: HAIR BIOLOGY AND SKIN BARRIER
Chairs: Carlos CLAVEL and Mayumi ITO
14:05 – 14:30
Colin JAHODA, Durham University, UK
The multifaceted roles of hair follicle mesenchymal cells and their epigenetic status in vivo and in vitro
14:30 – 14:45
Chin Yan LIM, Skin Research Institute of Singapore, Singapore
Dynamic changes in chromatin mediate epidermal development and keratinocyte function
14:45 – 15:00
Mikiro TAKAISHI, Kochi University, Japan
Ahed, an uncharacterized nuclear protein, is required for epidermal cell growth and differentiation
15:00 – 15:15
Nikolaos PANTELIREIS, Imperial College London, UK
Modelling epigenetic changes regulating hair follicle induction
15:15 – 15:30
Joy NG, Skin Research Institute of Singapore, Singapore
Sox2 in the dermal papilla regulates hair follicle pigmentation
15:30 – 16:00
Afternoon tea break
16:00 – 17:40
SESSION 10: HAIR BIOLOGY
Chairs: Colin JAHODA and Emi NISHIMURA
16:00 – 16:25
Mayumi ITO, New York University, USA
SHH signal in hair follicle neogenesis
16:25 – 16:40
Etienne Wang, National Skin Centre, Singapore
Oncostatin M from a distinct subset of TREM2+ macrophages inhibits hair follicle stem cells proliferation during telogen
16:40 – 16:55
Kenneth LAY, Institute of Medical Biology, Singapore
Hair follicle stem cells repurpose proliferation and recruit immune cells to contain a breach in their niche barrier
16:55 – 17:20
Hironobu FUJIWARA, RIKEN Center for Biosystems Dynamics Research, Japan
Developmental origin and induction processes of hair follicle stem cells
17:20 – 17:40
PRIZE CEREMONY AND CONFERENCE CLOSING
Thomas DAWSON, President, Skin Research Society Singapore
End of conference
CONFERENCE DINNER @ Privé, Asian Civilisations Museum