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Jessica STRID
"Pivotal roles for type 2 immunity in skin immune surveillance" Imperial College, London, UK |
Abstract
A high number of lymphocytes constitutively associate with epithelial tissues and these are called intraepithelial lymphocytes (IELs). IELs are not restricted to classical MHC and often express gd T cells receptors (TCRs). In this talk, I will discuss the capacity of gd TCR+ IELs in the skin to directly sense the health status of epithelial cells and to initiate a multifaceted response to promote homeostasis and tissue repair. By a variety of means IELs cross-communicate with epithelial cells to regulate their proliferation, differentiation, transit time through the epidermis and even DNA repair. We will particularly focus on the importance of type 2 immunity in mediating immune-surveillance and will address how IL-33 contributes to skin homeostasis via regulation of tissue-resident Treg. Overall, the talk will provide novel information on the versatile regulation of epithelial cells by type 2 immunity which ultimately strengthens the epithelial barrier and decreases susceptibility to damage and cancer development.
A high number of lymphocytes constitutively associate with epithelial tissues and these are called intraepithelial lymphocytes (IELs). IELs are not restricted to classical MHC and often express gd T cells receptors (TCRs). In this talk, I will discuss the capacity of gd TCR+ IELs in the skin to directly sense the health status of epithelial cells and to initiate a multifaceted response to promote homeostasis and tissue repair. By a variety of means IELs cross-communicate with epithelial cells to regulate their proliferation, differentiation, transit time through the epidermis and even DNA repair. We will particularly focus on the importance of type 2 immunity in mediating immune-surveillance and will address how IL-33 contributes to skin homeostasis via regulation of tissue-resident Treg. Overall, the talk will provide novel information on the versatile regulation of epithelial cells by type 2 immunity which ultimately strengthens the epithelial barrier and decreases susceptibility to damage and cancer development.
Bio
Jessica Strid is Professor of Cellular Immunology at the Department of Immunology and Inflammation, Imperial College London, UK. Dr Strid did her MSc degree at the Danish University of Pharmaceutical Sciences in Copenhagen, Denmark. She did her PhD in immunology at the Institute of Child Health, University College London, UK with a focus on food allergy and skin immunology. As a PostDoc she worked first at Kings College London and later at Cancer Research UK. Her PostDoc studies were focused on autologous sterile stress responses in the skin and their recognition by resident immune cells. In 2012 Dr Strid became an independent group leader and joined Imperial College London. The Strid laboratory studies immune surveillance at epithelial body surface tissues with a focus on understanding the role of tissue resident and infiltrating immune cells in regulating epithelial cell homeostasis, repair and carcinogenesis. The laboratory has a particular interest in the origins of Type 2 immunity and its role in immune stress-surveillance in the skin. The lab is funded by the Wellcome Trust, Cancer Research UK and the British Skin Foundation.
Jessica Strid is Professor of Cellular Immunology at the Department of Immunology and Inflammation, Imperial College London, UK. Dr Strid did her MSc degree at the Danish University of Pharmaceutical Sciences in Copenhagen, Denmark. She did her PhD in immunology at the Institute of Child Health, University College London, UK with a focus on food allergy and skin immunology. As a PostDoc she worked first at Kings College London and later at Cancer Research UK. Her PostDoc studies were focused on autologous sterile stress responses in the skin and their recognition by resident immune cells. In 2012 Dr Strid became an independent group leader and joined Imperial College London. The Strid laboratory studies immune surveillance at epithelial body surface tissues with a focus on understanding the role of tissue resident and infiltrating immune cells in regulating epithelial cell homeostasis, repair and carcinogenesis. The laboratory has a particular interest in the origins of Type 2 immunity and its role in immune stress-surveillance in the skin. The lab is funded by the Wellcome Trust, Cancer Research UK and the British Skin Foundation.
Chair
John COMMON, ASRL, Singapore
John COMMON, ASRL, Singapore