|
Hong Liang TEY
Delivering clinical solutions through dermal delivery of therapeutic agents |
Abstract
Topical therapeutic agents are invariably administered as formulated preparations, rather than as pure chemical compounds, for synergistic and combinational effects. The greatest barrier for dermal delivery of therapeutic agents to treat skin conditions is the impervious outermost layer of the skin – the stratum corneum. Various techniques can be used to enhance delivery across this barrier; these comprise passive methods (such as penetration enhancers and liposomes) and active approaches (such as iontophoresis, microneedles and electroporation). In this talk, we will present our experience in formulation and commercialisation of various topical products, and our innovations in using dissolving microneedles and iontophoresis for administration of therapeutic agents in our clinical practice.
Topical therapeutic agents are invariably administered as formulated preparations, rather than as pure chemical compounds, for synergistic and combinational effects. The greatest barrier for dermal delivery of therapeutic agents to treat skin conditions is the impervious outermost layer of the skin – the stratum corneum. Various techniques can be used to enhance delivery across this barrier; these comprise passive methods (such as penetration enhancers and liposomes) and active approaches (such as iontophoresis, microneedles and electroporation). In this talk, we will present our experience in formulation and commercialisation of various topical products, and our innovations in using dissolving microneedles and iontophoresis for administration of therapeutic agents in our clinical practice.
Bio
Dr. TEY Hong Liang is the Head of Research Division and Senior Consultant at the National Skin Centre (NSC). He is concurrently an Adjunct Associate Professor at Yong Loo Lin Medicine, National University of Singapore, and an Assistant Professor at Lee Kong Chian Medicine, Nanyang Technology University. His clinical and research interest is in neurodermatology, which comprises itch and sweat disorders. Leveraging on his platform capabilities in dermatological formulation, skin imaging and therapeutics-embedded dissolving microneedles, his works include 10 active patent filings, 184 international publications, and 12 products to date. Clinically, he has instituted 3 novel patent-filed treatments, implemented curative treatments for an idiopathic condition (hypohidrosis), and initiated 3 new clinical services in Singapore. He is a recipient of the National Medical Research Council Transition Award and Clinician Scientist Award, and the National Healthcare Group Outstanding Citizenship Award and Innovator of the Year (2020) Award. He is also an Associate Editor of ITCH, the official journal of the International Forum for the Study of Itch
Dr. TEY Hong Liang is the Head of Research Division and Senior Consultant at the National Skin Centre (NSC). He is concurrently an Adjunct Associate Professor at Yong Loo Lin Medicine, National University of Singapore, and an Assistant Professor at Lee Kong Chian Medicine, Nanyang Technology University. His clinical and research interest is in neurodermatology, which comprises itch and sweat disorders. Leveraging on his platform capabilities in dermatological formulation, skin imaging and therapeutics-embedded dissolving microneedles, his works include 10 active patent filings, 184 international publications, and 12 products to date. Clinically, he has instituted 3 novel patent-filed treatments, implemented curative treatments for an idiopathic condition (hypohidrosis), and initiated 3 new clinical services in Singapore. He is a recipient of the National Medical Research Council Transition Award and Clinician Scientist Award, and the National Healthcare Group Outstanding Citizenship Award and Innovator of the Year (2020) Award. He is also an Associate Editor of ITCH, the official journal of the International Forum for the Study of Itch
|
Sierin LIM
Protein nanocages for delivery of active ingredients |
Abstract
Protein nanocages have been engineered to enhance targeting and uptake by melanocytes. Loading of active ingredients is shown to enhance their activities, e.g. reduction of melanin and ROS.
Protein nanocages have been engineered to enhance targeting and uptake by melanocytes. Loading of active ingredients is shown to enhance their activities, e.g. reduction of melanin and ROS.
Bio
Sierin Lim is an associate professor of bioengineering at the School of Chemical and Biomedical Engineering and Associate Dean (Global Partnerships) at the Graduate College, Nanyang Technological University (NTU) Singapore. She earned her B.S. in Chemical Engineering and Ph.D. in Biomedical Engineering from University of California Los Angeles (UCLA) and did a postdoc at University of California Irvine Department of Chemical Engineering and Materials Science.
Her Bioengineered and Applied Nanomaterials Laboratory (BeANs Lab) at NTU focuses on the design and engineering of hybrid nano/microscale devices from biological parts by utilizing protein engineering as a tool for applications in health (therapeutics, food, consumer products) and the environment. She is the founding chair and advisor to the Biomedical Engineering Society (Singapore) Student Chapter and is one of the STEM ambassadors for United Women Singapore. In 2013 she received the L’Oréal-UNESCO Singapore for Women in Science National Fellowship and in 2020 the Inaugural list of Singapore 100 Women in Tech.
Sierin Lim is an associate professor of bioengineering at the School of Chemical and Biomedical Engineering and Associate Dean (Global Partnerships) at the Graduate College, Nanyang Technological University (NTU) Singapore. She earned her B.S. in Chemical Engineering and Ph.D. in Biomedical Engineering from University of California Los Angeles (UCLA) and did a postdoc at University of California Irvine Department of Chemical Engineering and Materials Science.
Her Bioengineered and Applied Nanomaterials Laboratory (BeANs Lab) at NTU focuses on the design and engineering of hybrid nano/microscale devices from biological parts by utilizing protein engineering as a tool for applications in health (therapeutics, food, consumer products) and the environment. She is the founding chair and advisor to the Biomedical Engineering Society (Singapore) Student Chapter and is one of the STEM ambassadors for United Women Singapore. In 2013 she received the L’Oréal-UNESCO Singapore for Women in Science National Fellowship and in 2020 the Inaugural list of Singapore 100 Women in Tech.
Chairs
Freda Lim, IHPC
Leah Vardy, SRIS
Etienne Wang, NSC
Freda Lim, IHPC
Leah Vardy, SRIS
Etienne Wang, NSC
Attendance is free but registration is required.
Kindly cancel your registration in case your plans change.
Kindly cancel your registration in case your plans change.