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Freda LIM
Modeling and Simulation in Consumer (Hair) Care |
Abstract
In the development of hair care products, molecular interactions of ingredients with the hair surface are important. However, the hair surface is a complex structure with large variations even within a single strand of a single human subject. Hence, we can expect that the variation to be even greater between individuals. To understand how ingredients adhere, coat and bring about desired benefits for our hair, it is important to understand these interactions and how it translates to benefits at real time and length scales. Therefore, besides modelling the molecular scale interactions occurring between different ingredients and the hair at the interacting interfaces, the IHPC team also performs simulations at larger time and length scales to translate the impact of the molecular information into their expected performance. With the models developed in IHPC, we investigate the interactions of ingredients on hair in variety of ways. In this short talk, I will be sharing some of the models which we have developed for the modeling and simulation of hair and scalp and their interaction with formulations.
In the development of hair care products, molecular interactions of ingredients with the hair surface are important. However, the hair surface is a complex structure with large variations even within a single strand of a single human subject. Hence, we can expect that the variation to be even greater between individuals. To understand how ingredients adhere, coat and bring about desired benefits for our hair, it is important to understand these interactions and how it translates to benefits at real time and length scales. Therefore, besides modelling the molecular scale interactions occurring between different ingredients and the hair at the interacting interfaces, the IHPC team also performs simulations at larger time and length scales to translate the impact of the molecular information into their expected performance. With the models developed in IHPC, we investigate the interactions of ingredients on hair in variety of ways. In this short talk, I will be sharing some of the models which we have developed for the modeling and simulation of hair and scalp and their interaction with formulations.
Bio
Freda Lim is the Deputy Department Director (Designate) at the Materials Science and Chemistry Department of the Institute of High-Performance Computing (IHPC). She is also currently jointly appointed as a Senior Scientist at the Formulated Products Division of the Institute of Chemical and Engineering Sciences (ICES). She has more than 17 years of working experience in the STEM industry after her PhD program with the Department of Chemistry at the National University of Singapore. Trained as a Computational Chemist looking at Surface Chemistry on Semiconductors and Catalysts surfaces, she has moved into the modeling and simulation of soft materials in 2010 and spent the past 10 years building modeling and simulation capabilities for application in the FMCG domain. Since 2016, Freda spearheaded computational research in the specialty chemical sector by securing a number of mission-critical industry alignment funds, which enabled her team to build a series of capabilities important for modeling the molecular interactions on hair, skin and formulation for the personal care and pharmaceutical industry. She interfaced actively with industry and academic stakeholders in order to foster strong connections and bridge gaps to seed collaboration opportunities.
Freda Lim is the Deputy Department Director (Designate) at the Materials Science and Chemistry Department of the Institute of High-Performance Computing (IHPC). She is also currently jointly appointed as a Senior Scientist at the Formulated Products Division of the Institute of Chemical and Engineering Sciences (ICES). She has more than 17 years of working experience in the STEM industry after her PhD program with the Department of Chemistry at the National University of Singapore. Trained as a Computational Chemist looking at Surface Chemistry on Semiconductors and Catalysts surfaces, she has moved into the modeling and simulation of soft materials in 2010 and spent the past 10 years building modeling and simulation capabilities for application in the FMCG domain. Since 2016, Freda spearheaded computational research in the specialty chemical sector by securing a number of mission-critical industry alignment funds, which enabled her team to build a series of capabilities important for modeling the molecular interactions on hair, skin and formulation for the personal care and pharmaceutical industry. She interfaced actively with industry and academic stakeholders in order to foster strong connections and bridge gaps to seed collaboration opportunities.
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Carlos CLAVEL
Regulation of Skin Homeostasis by the Hair Follicle |
Abstract
In our body, organ homeostasis is tightly orchestrated by signals from the stem cell niche that dictate the capacity of the stem cells to self-renewal or differentiate. And in the skin, the main stem cell reservoir is found within the hair follicle stem cell niche. Thanks to our collaborators, we are establishing a hair research program by combining basic research, bioengineering and clinical expertise in the skin. We are developing novel in vitro and in vivo tools to investigate intrinsic and extrinsic regulations of hair and skin pigmentation, during normal development or skin disorders. During this seminar, I will be presenting some of our ongoing projects where we are using these novel tools to showcase the key role of the hair follicle to sustain normal growth and skin pigmentation.
In our body, organ homeostasis is tightly orchestrated by signals from the stem cell niche that dictate the capacity of the stem cells to self-renewal or differentiate. And in the skin, the main stem cell reservoir is found within the hair follicle stem cell niche. Thanks to our collaborators, we are establishing a hair research program by combining basic research, bioengineering and clinical expertise in the skin. We are developing novel in vitro and in vivo tools to investigate intrinsic and extrinsic regulations of hair and skin pigmentation, during normal development or skin disorders. During this seminar, I will be presenting some of our ongoing projects where we are using these novel tools to showcase the key role of the hair follicle to sustain normal growth and skin pigmentation.
Bio
Carlos Clavel received his BS and MS in Biological Sciences from Saint Louis University in the US. He finished his Ph.D. training in Cell Therapy at the University of Navarra, Spain. Then, he joined the laboratory of Dr. Catherine Verfaillie working with Multipotent Adult Progenitor Cells in her laboratories of Minnesota (US) and Leuven (Belgium). His research then shifted to understanding how stem cells are instructed to display their potential, and he subsequently joined Dr. Michael Rendl’s laboratory at Icahn School of Medicine at Mount Sinai in New York where his research focused on the transcriptional control of the hair inducing fate of Dermal Papilla niche cells. Carlos is now a Principal Investigator at the A*Star Skin Research Labs (ASRL) where his group is focusing on understanding the regulation of the hair follicle stem cell niche and its implication in novel therapies for skin disorders.
Carlos Clavel received his BS and MS in Biological Sciences from Saint Louis University in the US. He finished his Ph.D. training in Cell Therapy at the University of Navarra, Spain. Then, he joined the laboratory of Dr. Catherine Verfaillie working with Multipotent Adult Progenitor Cells in her laboratories of Minnesota (US) and Leuven (Belgium). His research then shifted to understanding how stem cells are instructed to display their potential, and he subsequently joined Dr. Michael Rendl’s laboratory at Icahn School of Medicine at Mount Sinai in New York where his research focused on the transcriptional control of the hair inducing fate of Dermal Papilla niche cells. Carlos is now a Principal Investigator at the A*Star Skin Research Labs (ASRL) where his group is focusing on understanding the regulation of the hair follicle stem cell niche and its implication in novel therapies for skin disorders.
Chairs
Srikala Raghavan, ASRL
Aishwarya Sridharan, ASRL
Srikala Raghavan, ASRL
Aishwarya Sridharan, ASRL