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Pritinder KAUR
"Pericytes and human skin regeneration" Curtin Health Innovation Research Institute |
Abstract
Our lab's interest in understanding the role of epidermal:mesenchymal interactions in promoting epidermal renewal in human skin led us to uncover a potential role for dermal pericytes as paracrine regulators - in addition to their recognised role in regulating blood vessel structure and function. We have begun to exploit both these aspects of pericyte function to promote human skin regeneration in various in vitro and in vivo models, while simultaneously investigating pericyte heterogeneity using scRNA seq approaches. The data we have generated recently provides insights into how we might begin to engineer 3D skin constructs to incorporate microvascularisation, how we might translate our findings into a large animal model using bioprinting approaches and assess the extent of pericyte heterogeneity in neonatal human skin These unpublished findings will be discussed in my seminar.
Our lab's interest in understanding the role of epidermal:mesenchymal interactions in promoting epidermal renewal in human skin led us to uncover a potential role for dermal pericytes as paracrine regulators - in addition to their recognised role in regulating blood vessel structure and function. We have begun to exploit both these aspects of pericyte function to promote human skin regeneration in various in vitro and in vivo models, while simultaneously investigating pericyte heterogeneity using scRNA seq approaches. The data we have generated recently provides insights into how we might begin to engineer 3D skin constructs to incorporate microvascularisation, how we might translate our findings into a large animal model using bioprinting approaches and assess the extent of pericyte heterogeneity in neonatal human skin These unpublished findings will be discussed in my seminar.
Bio
Current position: Associate Professor/Lab Head, Curtin Health Innovation Research Institute, Curtin Medical School, Curtin University, Perth Research Interests: I am an epithelial stem cell biologist with research interests in tissue renewal, wound repair, ageing and cancer. My laboratory has used predominantly human skin as a model epithelium. My primary research interests focus on understanding the cellular and molecular interactions between epithelial stem and progenitor cells and their immediate mesenchymal microenvironment - an interaction that drives homeostatic cell replacement, wound repair, carcinogenesis and ageing. Brief Bio BSc Hons in Cell Biology : University of London, UK PhD : Paterson Insttute of Cancer Research affiliated to Manchester University, UK Postdoctoral training : Human papillomaviruses and epithelial carcinogenesis, Laboratory of James K McDougall, Basic Sciences Division, Fred Hutchinson Cancer Centre, Seattle, USA; Integrins in keratinocyte adhesion and carcinogenesis, Laboratory of William G Carter, Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, USA Lab Head: Hanson Centre for Cancer Research, Adelaide; Peter MacCallum Cancer Centre, Melbourne; Hudson Institute, Melbourne; Curtin University, Perth Other interesting facts: Editor for the journal "Stem Cells" since 2004 Member, Expert Advisory Panel on the MRFF Stem Cell Therapies Mission to the Minister for Health, Greg Hunt 2020-2021 Vice President, Australasian Wound Healing & Tissue Research Society 2019-present Head, Scientific Committee, Australasian Society for Dermatology Research 2018-present
Current position: Associate Professor/Lab Head, Curtin Health Innovation Research Institute, Curtin Medical School, Curtin University, Perth Research Interests: I am an epithelial stem cell biologist with research interests in tissue renewal, wound repair, ageing and cancer. My laboratory has used predominantly human skin as a model epithelium. My primary research interests focus on understanding the cellular and molecular interactions between epithelial stem and progenitor cells and their immediate mesenchymal microenvironment - an interaction that drives homeostatic cell replacement, wound repair, carcinogenesis and ageing. Brief Bio BSc Hons in Cell Biology : University of London, UK PhD : Paterson Insttute of Cancer Research affiliated to Manchester University, UK Postdoctoral training : Human papillomaviruses and epithelial carcinogenesis, Laboratory of James K McDougall, Basic Sciences Division, Fred Hutchinson Cancer Centre, Seattle, USA; Integrins in keratinocyte adhesion and carcinogenesis, Laboratory of William G Carter, Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, USA Lab Head: Hanson Centre for Cancer Research, Adelaide; Peter MacCallum Cancer Centre, Melbourne; Hudson Institute, Melbourne; Curtin University, Perth Other interesting facts: Editor for the journal "Stem Cells" since 2004 Member, Expert Advisory Panel on the MRFF Stem Cell Therapies Mission to the Minister for Health, Greg Hunt 2020-2021 Vice President, Australasian Wound Healing & Tissue Research Society 2019-present Head, Scientific Committee, Australasian Society for Dermatology Research 2018-present
Chair
Srikala Raghavan, ASRL, Singapore
Srikala Raghavan, ASRL, Singapore